I have finally wrapped up Mass Effect Andromeda after some 80 game hours. It's a beast of a game, with some open world filler, but overall I had a pretty good time with it.
The combat was fun all the way through. Maybe that was a product of my character build choices--shotgun-centric, making liberal use of the dash and jump, with a heavy dose of melee damage and shield drain and fire thrower abilities from the tech skill path.
Plot-wise, Andromeda is pretty successful pseudo-reboot, set apart from the events of the original Mass Effect trilogy in both time and space. It's the story of the Milky Way races establishing a new home in a new galaxy, while at the same time helping the Heleus native Angara to fend of a militaristic empire of gene-consuming race assimilators called the Kett, to deal with the remains of an ancient race's AI constructs, and to weather the fallout of an apocalyptic war in the sector in the years the Andromeda Initiative arks were in transit from the Milky Way.
At the end of the game, a foothold is gained, allies made, and the Kett Archon fended off, but the rest of the Kett are still out there in the galaxy, one last ark is still making its way in Andromeda, and the Pathfinder and crew still have a job to do exploring and building a new civilization in their new home.
EA has made noises that sound like the game didn't perform to expectations, and while that's not hard to believe, given said expectations, I do hope we'll see a continuation of the series in Andromeda. Maybe DLC to begin with, to cover the arrival of the Quarians and other Milky Way races, and another game in the future, possibly a generation later, exploring the further integration of the new arrivals with the natives, and the looming threat of the Kett Empire.
In all likelihood, we get either the first or neither at all.